B cells produce antibodies, while T cells target and eliminate infected cells. Further tests were conducted 28 days after each immunization to measure the activity of B and T cells, both of which play a crucial role in the immune response.
The participants in the study had their blood samples collected immediately after receiving each dose of either the Oxford/AstraZeneca or Pfizer/BioNTech COVID-19 vaccine, in order to evaluate their early immune response. The findings, published in Cell Reports Medicine, are part of the COVID-19 Vaccine Immune Responses Study (COVIRS) and were based on the analysis of the immune responses of 102 adults of various ages residing in South Australia, where there was no SARS-CoV-2 community transmission at the time of the study. Scientists identify key differences in immune responses to the AstraZeneca and Pfizer vaccines.Ī recent study conducted by a team from SAHMRI and Flinders University in Australia has revealed significant variations in the way the AstraZeneca and Pfizer COVID-19 vaccines affect the immune system. Booster doses, particularly mRNA ones, were found to be crucial for enhancing immune responses. The AstraZeneca vaccine elicited an unexpected memory-like response, potentially explaining its rare association with blood clotting, while the Pfizer vaccine induced stronger B and T cell activity. A recent Australian study discovered fundamental differences in immune responses between the AstraZeneca and Pfizer COVID-19 vaccines.
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